
基本信息:
- 专利标题: ANTIBODY SCREENING METHODS
- 专利标题(中):抗体筛选过程
- 申请号:EP12757543.9 申请日:2012-03-14
- 公开(公告)号:EP2686349A2 公开(公告)日:2014-01-22
- 发明人: CHEN, Yan , WOOLF, Tod, M. , WAGNER, Richard, W.
- 申请人: X-Body, Inc.
- 申请人地址: 100 Beaver Street, Suite 101 Waltham, MA 02453 US
- 专利权人: X-Body, Inc.
- 当前专利权人: X-Body, Inc.
- 当前专利权人地址: 100 Beaver Street, Suite 101 Waltham, MA 02453 US
- 代理机构: De Clercq, Ann G. Y.
- 优先权: US201161453106P 20110315; US201161566778P 20111205
- 国际公布: WO2012125733 20120920
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C40B40/10 ; G01N33/53
摘要:
Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
公开/授权文献:
- EP2686349B1 ANTIBODY SCREENING METHODS 公开/授权日:2020-12-09
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07K | 肽 |
------C07K16/00 | 免疫球蛋白,例如,单克隆或多克隆抗体 |
--------C07K16/18 | .来自动物或人的抵抗物质 |
----------C07K16/28 | ..抗受体,细胞表面抗原或细胞表面决定因子 |