基本信息:
- 专利标题： VIRUS LIKE PARTICLE PRODUCTION IN PLANTS
- 专利标题（中）：生产病毒样颗粒在植物
- 申请号：EP11851176.5 申请日：2011-12-22
- 公开(公告)号：EP2655613A1 公开(公告)日：2013-10-30
- 发明人： D'AOUST, Marc-Andre , COUTURE, Manon , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe
- 申请人： Medicago Inc.
- 申请人地址： 1020 route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- 专利权人： Medicago Inc.
- 当前专利权人： Medicago Inc.
- 当前专利权人地址： 1020 route de l'Eglise Suite 600 Québec, Québec G1V 3V9 CA
- 代理机构： van Kooij, Adriaan
- 优先权： US201061426401P 20101222; US201161496371P 20110613
- 国际公布： WO2012083445 20120628
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A61K39/295 ; A61P31/16 ; A61P37/04 ; C07K19/00 ; C12N15/62 ; C12N15/82 ; C12N7/00 ; C07K14/005 ; C07K14/11
摘要：
A method of producing a virus like particle (VLP) in a plant, and compositions comprising VLPs, are provided. The method involves introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a chimeric nucleotide sequence encoding, in series, an ectodomain from a virus trimeric surface protein or fragment thereof, fused to an influenza transmembrane domain and cytoplasmic tail, into the plant, or portion of the plant, the ectodomain is from a non- influenza virus trimeric surface protein and heterologous with respect to the influenza transmembrane domain, and the cytoplasmic tail. The plant or portion of the plant are incubated under conditions that permit the expression of the nucleic acid, thereby producing the VLP. A VLP produced by this method are also provided.
公开/授权文献:
- EP2655613B1 VIRUS LIKE PARTICLE PRODUCTION IN PLANTS 公开/授权日：2017-02-15