基本信息:
- 专利标题： HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF
- 专利标题（中）：HISTON-ACETYLTRANSFERASE-MODULATOREN UND VERWENDUNGEN DAVON
- 申请号：EP11850544.5 申请日：2011-12-22
- 公开(公告)号：EP2654428A1 公开(公告)日：2013-10-30
- 发明人： FRANCIS, Yitshak , FA, Mauro , ARANCIO, Ottavio , FIORITO, Jole , DENG, Shixian , LANDRY, Donald, W. , LUZAC, Michal , FENG, Yan
- 申请人： The Trustees of Columbia University in the City of New York
- 申请人地址： 412 Low Memorial Library 535 West 116th Street New York, New York 10027 US
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： 412 Low Memorial Library 535 West 116th Street New York, New York 10027 US
- 代理机构： Lawrence, John
- 优先权： US201161539697P 20110927; US201161541706P 20110930; US201061426033P 20101222
- 国际公布： WO2012088420 20120628
- 主分类号： A01N55/02
- IPC分类号： A01N55/02
摘要：
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
摘要（中）：
本发明提供了包含调节组蛋白酰基转移酶（HAT）的化合物的化合物和组合物。 本发明还提供了通过向受试者施用调节HAT的化合物来治疗神经变性疾病，与累积的淀粉样蛋白-β肽沉积相关的病症，Tau蛋白水平和/或α-突触核蛋白的积累以及癌症的方法。
公开/授权文献:
- EP2654428B1 HISTONE ACETYLTRANSFERASE MODULATORS AND USESE THEREOF 公开/授权日：2018-02-14