发明公开
EP2640392A2 SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO)PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF
有权
基本信息:
- 专利标题： SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO)PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF
- 专利标题（中）：取代的4-（硒吩-2-（或3-）基氨基）嘧啶化合物和使用THEREFOR的方法
- 申请号：EP11841996.9 申请日：2011-11-17
- 公开(公告)号：EP2640392A2 公开(公告)日：2013-09-25
- 发明人： GOKARAJU, Ganga Raju , KASINA, Sudhakar , SOMEPALLI, Venkateswarlu , GOKARAJU, Rama Raju , GOKARAJU, Venkata Kanaka Ranga Raju , BHUPATHIRAJU, Kiran , GOLAKOTI, Trimurtulu , SENGUPTA, Krishanu , ALLURI, Venkata Krishna Raju
- 申请人： Kasina Laila Innova Pharmaceuticals Private Ltd.
- 申请人地址： 40-15-14 Brindavan Colony Labbipet Vijayawada 520 010 Andhra Pradesh IN
- 专利权人： Kasina Laila Innova Pharmaceuticals Private Ltd.
- 当前专利权人： Kasina Laila Innova Pharmaceuticals Private Ltd.
- 当前专利权人地址： 40-15-14 Brindavan Colony Labbipet Vijayawada 520 010 Andhra Pradesh IN
- 代理机构： Isarpatent
- 优先权： INCH34682010 20101118
- 国际公布： WO2012066578 20120524
- 主分类号： A61K31/517
- IPC分类号： A61K31/517
摘要：
Selenophene compounds of formula (I) are described herein. In the compounds of Formula (I), ring A is a 6-membered aromatic fused ring, optionally containing one, two or three nitrogen atoms; a 5-membered heteroaromatic fused ring; or a mono- or bicyclic saturated heterocyclic fused ring having at least one ring member selected from the group consisting of N, O, S, SO and SO2; Y in ring B is nitrogen or substituted carbon; X is NR6, O, S, S(O), or S(O)2. R1, R2, R3, R4, and R6 are defined in the specification. Selenophene compounds of formula (I) may be used in methods of treating cell proliferative disorders, particularly cancer. Pharmaceutical compositions containing selenophene compounds of formula (I) may be used for treatment, inhibition, or control of cancer.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/50 | ....哒嗪；氢化哒嗪 |
| ----------------A61K31/517 | .....与碳环系统邻位或迫位稠合的，例如喹唑啉、萘嵌间二氮杂苯 |