发明公开
EP2638001A1 VERFAHREN ZUR HERSTELLUNG VON 2,2-DIFLUORETHYLAMIN AUSGEHEND VON PROP-2-EN-1-AMIN
有权
基本信息:
- 专利标题： VERFAHREN ZUR HERSTELLUNG VON 2,2-DIFLUORETHYLAMIN AUSGEHEND VON PROP-2-EN-1-AMIN
- 专利标题（英）：Method for preparing 2,2-difluoroethylamine starting from prop-2-en-1-amine
- 专利标题（中）：用于生产丙-2-烯-1- AMIN 1,2-二氟乙胺BASIS
- 申请号：EP11778923.0 申请日：2011-11-07
- 公开(公告)号：EP2638001A1 公开(公告)日：2013-09-18
- 发明人： LUI, Norbert , FUNKE, Christian , HEINRICH, Jens-Dietmar , MÜLLER, Thomas, Norbert
- 申请人： Bayer Intellectual Property GmbH
- 申请人地址： Alfred-Nobel-Str. 10 40789 Monheim am Rhein DE
- 专利权人： Bayer Intellectual Property GmbH
- 当前专利权人： Bayer Intellectual Property GmbH
- 当前专利权人地址： Alfred-Nobel-Str. 10 40789 Monheim am Rhein DE
- 代理机构： BIP Patents
- 优先权： US413059P 20101112; EP10191059 20101112
- 国际公布： WO2012062703 20120518
- 主分类号： C07C209/08
- IPC分类号： C07C209/08 ; C07C209/62 ; C07C211/24
摘要：
A method for preparing 2,2-difluoroethylamine of formula (I) CHF
2 CH
2 NH
2 comprises steps (i) and (ii). In step (i), 2,2-difluoro-1-halogen ethane of formula (II) CHF
2 -CH
2 HAl, in which Hal stands for chlorine, bromine or iodine, is reacted with prop-2-en-1-amine of formula (III), to form N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV), preferably in the presence of an acid scavenger. In step (ii), the allyl group is removed from the N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV) obtained in step (i) to form 2,2-difluoroethylamine of formula (I) or a salt thereof.
2 CH
2 NH
2 comprises steps (i) and (ii). In step (i), 2,2-difluoro-1-halogen ethane of formula (II) CHF
2 -CH
2 HAl, in which Hal stands for chlorine, bromine or iodine, is reacted with prop-2-en-1-amine of formula (III), to form N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV), preferably in the presence of an acid scavenger. In step (ii), the allyl group is removed from the N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV) obtained in step (i) to form 2,2-difluoroethylamine of formula (I) or a salt thereof.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C209/00 | 含氨基连接在碳架上的化合物的制备 |
| --------C07C209/04 | .用氨基取代官能团 |
| ----------C07C209/06 | ..取代卤原子 |
| ------------C07C209/08 | ...生成的氨基连接在非环碳原子上或连接除六元芳环以外的其他环的碳原子上 |