基本信息:
- 专利标题： MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME
- 专利标题（中）：可溶性聚IL-15融合分子和方法的生产和使用
- 申请号：EP11827439.8 申请日：2011-09-21
- 公开(公告)号：EP2619229A2 公开(公告)日：2013-07-31
- 发明人： WONG, Hing, C. , RHODE, Peter , LIU, Bai , ZHU, Xiaoyun , HAN, Kai-ping
- 申请人： Altor BioScience Corporation
- 申请人地址： 2810 North Commerce Parkway Miramar, Florida 33025 US
- 专利权人： Altor BioScience Corporation
- 当前专利权人： Altor BioScience Corporation
- 当前专利权人地址： 2810 North Commerce Parkway Miramar, Florida 33025 US
- 代理机构： Hiebl, Inge Elisabeth
- 优先权： US384817P 20100921; US201161527911P 20110826
- 国际公布： WO2012040323 20120329
- 主分类号： C07K19/00
- IPC分类号： C07K19/00 ; C07K14/54 ; C07K14/075 ; C12N15/62 ; A61K38/17 ; A61P35/00
摘要：
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin- 15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.