发明公开
EP2592064A1 PROCESS FOR PRODUCTION OF PURIFIED CHLOROGENIC ACID-CONTAINING PHARMACEUTICAL PREPARATION
有权
基本信息:
- 专利标题： PROCESS FOR PRODUCTION OF PURIFIED CHLOROGENIC ACID-CONTAINING PHARMACEUTICAL PREPARATION
- 专利标题（中）：PROCESS一种精制CHLOROGENSÄUREHALTIGEN配药设备
- 申请号：EP11803627.6 申请日：2011-07-06
- 公开(公告)号：EP2592064A1 公开(公告)日：2013-05-15
- 发明人： SUGIYAMA, Yukiteru , YAMAWAKI, Kenji , KUBO, Yuko
- 申请人： Kao Corporation
- 申请人地址： 14-10, Nihonbashi-Kayabacho, 1-chome Chuo-ku Tokyo 103-8210 JP
- 专利权人： Kao Corporation
- 当前专利权人： Kao Corporation
- 当前专利权人地址： 14-10, Nihonbashi-Kayabacho, 1-chome Chuo-ku Tokyo 103-8210 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2010153783 20100706
- 国际公布： WO2012005293 20120112
- 主分类号： C07C67/56
- IPC分类号： C07C67/56 ; C07C69/013 ; C07C69/732
摘要：
Provided is a process for producing a purified "chlorogenic acid-containing preparation, which is useful for the production of a chlorogenic acid-containing beverage with reduced developability of turbidity even in an acidic range.
The process for producing a purified chlorogenic acid-containing preparation according to the present invention includes a first step of dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of an organic solvent and water, a second step of removing a deposit from a dispersion or solution obtained by the first step, a third step of adjusting a concentration of chlorogenic acids and pH in a solution, which has been obtained by the second step, to from 1.5 to 10 mass% and from 2 to 4, respectively, and a fourth step of separating the deposit formed in a concentration-adjusted solution obtained by the third step.
The process for producing a purified chlorogenic acid-containing preparation according to the present invention includes a first step of dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of an organic solvent and water, a second step of removing a deposit from a dispersion or solution obtained by the first step, a third step of adjusting a concentration of chlorogenic acids and pH in a solution, which has been obtained by the second step, to from 1.5 to 10 mass% and from 2 to 4, respectively, and a fourth step of separating the deposit formed in a concentration-adjusted solution obtained by the third step.