发明公开
EP2588122A4 PERLECAN DOMAIN V PROTECTS, REPAIRS AND RESTORES ISCHEMIC BRAIN STROKE INJURY AND MOTOR FUNCTION
有权

基本信息:
- 专利标题: PERLECAN DOMAIN V PROTECTS, REPAIRS AND RESTORES ISCHEMIC BRAIN STROKE INJURY AND MOTOR FUNCTION
- 专利标题(中):PERLECANDOMÄNEV ZUR REHABILITATION NACHSCHLAGANFÄLLENUND ZUR WIEDERHERSTELLUNG DER MOTORIK
- 申请号:EP11801495 申请日:2011-07-01
- 公开(公告)号:EP2588122A4 公开(公告)日:2013-12-18
- 发明人: BIX GREGORY J
- 申请人: TEXAS A & M UNIV SYS
- 专利权人: TEXAS A & M UNIV SYS
- 当前专利权人: TEXAS A & M UNIV SYS
- 优先权: US36073910 2010-07-01
- 主分类号: A61K38/16
- IPC分类号: A61K38/16 ; A61K38/17 ; A61P9/10 ; A61P25/00
摘要:
The disclosed invention relates to the use of perlecan domain V (DV) for the treatment of stroke, traumatic brain injury (TBI) or spinal cord injuries (SCI). In certain embodiments, fusion proteins of DV can be used for the treatment of stroke, TBI or SCI. DV is also referred to as endorepellin in the art. This application also provides compositions and combination therapies for the treatment of stroke, TCI and/or SCI. Another aspect of the invention provides methods of restoring motor function in subjects having neurological damage arising from a stroke, TBI or SCI.
摘要(中):
所公开的发明涉及基底膜蛋白聚糖结构域V(DV)用于治疗中风,创伤性脑损伤(TBI)或脊髓损伤(SCI)的用途。 在某些实施方案中,DV的融合蛋白可用于治疗中风,TBI或SCI。 DV在本领域中也被称为endorepellin。 该应用还提供用于治疗中风,TCI和/或SCI的组合物和组合疗法。 本发明的另一方面提供了在具有由中风,TBI或SCI引起的神经损伤的受试者中恢复运动功能的方法。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K38/00 | 含肽的医药配制品 |
--------A61K38/16 | .含有20个以上氨基酸的肽;胃泌激素;生长素抑制素;促黑激素;其衍生物 |