发明公开
EP2519816A2 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST
审中-公开
基本信息:
- 专利标题： METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST
- 专利标题（中）：法发现从天然产物药理活性物质使用高分辨率质谱及药理活性试验
- 申请号：EP10841161.2 申请日：2010-12-15
- 公开(公告)号：EP2519816A2 公开(公告)日：2012-11-07
- 发明人： PARK, Kyu Hwan , KIM, Hyun Sik , KWON, Kyung Hoon , YOO, Jong Shin
- 申请人： Korea Basic Science Institute
- 申请人地址： 52 Eoeun-dong Yusung-gu Daejeon 305-333 KR
- 专利权人： Korea Basic Science Institute
- 当前专利权人： Korea Basic Science Institute
- 当前专利权人地址： 52 Eoeun-dong Yusung-gu Daejeon 305-333 KR
- 代理机构： Höglund, Lars
- 优先权： KR20090133083 20091229
- 国际公布： WO2011081329 20110707
- 主分类号： G01N30/72
- IPC分类号： G01N30/72 ; G01N33/15 ; B01D15/08
摘要：
Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
公开/授权文献:
IPC结构图谱:
| G | 物理 |
| --G01 | 测量；测试 |
| ----G01N | 借助于测定材料的化学或物理性质来测试或分析材料 |
| ------G01N30/00 | 利用吸附作用、吸收作用或类似现象，或者利用离子交换，例如色谱法将材料分离成各个组分，来测试或分析材料 |
| --------G01N30/02 | .柱色谱法 |
| ----------G01N30/62 | ..相应的专用检测器 |
| ------------G01N30/72 | ...质谱仪 |