发明公开
EP2479174A1 6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
有权
基本信息:
- 专利标题： 6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
- 专利标题（中）：6-氨基 - 喹唑啉或3 CYAN-的喹啉衍生物和方法及其制造和药物应用
- 申请号：EP10814867.7 申请日：2010-08-26
- 公开(公告)号：EP2479174A1 公开(公告)日：2012-07-25
- 发明人： TANG, Peng Cho , LI, Xin , WANG, Bin , WANG, Jun , CHEN, Lijun
- 申请人： Jiangsu Hengrui Medicine Co., Ltd. , Shanghai Hengrui Pharmaceutical Co. Ltd.
- 申请人地址： No. 145 Renmin East Road Xinpu District Lianyungang, Jiangsu 222002 CN
- 专利权人： Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co. Ltd.
- 当前专利权人： Jiangsu Hengrui Medicine Co., Ltd.,Shanghai Hengrui Pharmaceutical Co. Ltd.
- 当前专利权人地址： No. 145 Renmin East Road Xinpu District Lianyungang, Jiangsu 222002 CN
- 代理机构： Jansen, Cornelis Marinus
- 优先权： CN200910195823 20090914
- 国际公布： WO2011029265 20110317
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07F9/6558 ; A61K31/4709 ; A61K31/517 ; A61P43/00 ; A61P35/00
摘要：
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/02 | .含有两个杂环 |
| ----------C07D401/12 | ..被含有杂原子的链作为键链连接的 |