发明公开
EP2440231A2 CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY
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基本信息:
- 专利标题： CO-ADMINISTRATION OF AN AGENT LINKED TO AN INTERNALIZATION PEPTIDE WITH AN ANTI-INFLAMMATORY
- 专利标题（中）：共施用WITH A INTERNALISIERUNGSPEPTID补救和抗炎药联
- 申请号：EP10786870.5 申请日：2010-06-10
- 公开(公告)号：EP2440231A2 公开(公告)日：2012-04-18
- 发明人： TYMIANSKI, Michael , GARMAN, Jonathan David , CUI, Hong
- 申请人： Nono, Inc.
- 申请人地址： 88 Strath Avenue Toronto, ON M8X 1R5 CA
- 专利权人： Nono, Inc.
- 当前专利权人： NONO INC.
- 当前专利权人地址： NONO INC.
- 代理机构： Green, Mark Charles
- 优先权： US185943P 20090610
- 国际公布： WO2010144742 20101216
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/10 ; A61K38/08 ; A61K31/275 ; A61P29/00 ; A61P9/00
摘要：
The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat at high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K38/00 | 含肽的医药配制品 |
| --------A61K38/16 | .含有20个以上氨基酸的肽；胃泌激素；生长素抑制素；促黑激素；其衍生物 |