基本信息:
- 专利标题： Hydroxyl compounds and compositions for cholesterol management and related uses
- 专利标题（中）：用于胆固醇管理和相关用途的羟基化合物和组合物
- 申请号：EP11005303.0 申请日：2003-12-23
- 公开(公告)号：EP2404890B1 公开(公告)日：2017-07-26
- 发明人： Dasseux, Jean-Louis, Henri , Oniciu, Daniela, Carmen
- 申请人： Esperion Therapeutics Inc.
- 申请人地址： 3891 Ranchero Drive, Suite 150 Ann Arbor, MI 48108 US
- 专利权人： Esperion Therapeutics Inc.
- 当前专利权人： ESPERION THERAPEUTICS INC.
- 当前专利权人地址： ESPERION THERAPEUTICS INC.
- 代理机构： Schnappauf, Georg
- 优先权： US441795P 20030123
- 主分类号： C07C31/22
- IPC分类号： C07C31/22 ; C07C31/20 ; C07C59/105 ; C07C59/245 ; C07C261/04 ; C07C311/24 ; A61P3/10 ; A61K31/047 ; A61K31/20 ; A61K31/23 ; A61K31/33
摘要：
The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics; such as hypocholesterolemic and hypoglycemic agents.
摘要（中）：
本发明涉及新颖的羟基化合物，包含羟基化合物的组合物以及用于治疗和预防多种疾病和病症的方法，所述疾病和病症例如但不限于衰老，阿尔茨海默病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病， 葡萄糖代谢障碍，血脂异常，异常脂蛋白血症，高血压，阳痿，炎症，胰岛素抵抗，胆汁中脂质消除，肥胖症，胆汁中氧固醇消除，胰腺炎，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症， 胆汁，肾脏疾病，败血症，代谢综合征病症（例如X综合征），血栓形成病症。 本发明的化合物和方法还可以用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其他治疗剂的组合疗法; 如降胆固醇药和降血糖药。