EP2403605B1 Compositions comprising an aP2-specific antibody or a fragment thereof for use in treating diabetes, glucose intolerance or obesity-induced insulin resistance
有权
基本信息:
- 专利标题： Compositions comprising an aP2-specific antibody or a fragment thereof for use in treating diabetes, glucose intolerance or obesity-induced insulin resistance
- 专利标题（中）：含有特定的aP2抗体组合物或用于糖尿病，葡萄糖耐受不良或肥胖诱导的胰岛素抵抗的治疗中的用途及其结合片段
- 申请号：EP10707783.6 申请日：2010-03-05
- 公开(公告)号：EP2403605B1 公开(公告)日：2015-05-06
- 发明人： HOTAMISLIGIL, Gokhan, S. , CAO, Haiming
- 申请人： President and Fellows of Harvard College
- 申请人地址： 17 Quincy Street Cambridge, MA 02138 US
- 专利权人： President and Fellows of Harvard College
- 当前专利权人： President and Fellows of Harvard College
- 当前专利权人地址： 17 Quincy Street Cambridge, MA 02138 US
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo LLP
- 优先权： US299170P 20100128; US209251P 20090305
- 国际公布： WO2010102171 20100910
- 主分类号： A61P3/10
- IPC分类号： A61P3/10 ; A61P3/08 ; A61K39/00 ; C07K16/18
摘要：
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.
公开/授权文献:
- EP2403605A2 Secreted ap2 and methods of inhibiting same 公开/授权日：2012-01-11
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61P | 化合物或药物制剂的治疗活性 |
| ------A61P3/00 | 治疗代谢疾病的药物 |
| --------A61P3/08 | .用于葡萄糖体内平衡的药物 |
| ----------A61P3/10 | ..治疗高血糖症的药物，例如抗糖尿病药 |