EP2300455B1 SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME
有权
转让
![SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME](/ep/2017/07/19/EP2300455B1/abs.jpg.150x150.jpg)
基本信息:
- 专利标题： SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)- IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME
- 申请号：EP09751439.2 申请日：2009-05-20
- 公开(公告)号：EP2300455B1 公开(公告)日：2017-07-19
- 发明人： WENG, Lingkai , QIAO, Lei , ZHOU, Jiacheng , LIU, Pingli , PAN, Yongchun
- 申请人： Incyte Holdings Corporation
- 申请人地址： 1801 Augustine Cut-Off Wilmington, DE 19803 US
- 专利权人： Incyte Holdings Corporation
- 当前专利权人： INCYTE HOLDINGS CORPORATION
- 当前专利权人地址： INCYTE HOLDINGS CORPORATION
- 代理机构： D Young & Co LLP
- 优先权： US54995P 20080521
- 国际公布： WO2009143211 20091126
- 主分类号： C07D401/10
- IPC分类号： C07D401/10 ; C07D487/04 ; C07D253/07 ; A61K31/53 ; A61P35/00
摘要：
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/02 | .含有两个杂环 |
| ----------C07D401/10 | ..被含芳环的碳链连接的 |