EP2261378B1 Method of preventing virus:cell fusion by inhibiting the function of the fusion initiation region in RNA viruses having class i membrane fusogenic envelope proteins
有权
基本信息:
- 专利标题： Method of preventing virus:cell fusion by inhibiting the function of the fusion initiation region in RNA viruses having class i membrane fusogenic envelope proteins
- 专利标题（中）：通过抑制具有I类膜融合包膜蛋白的RNA病毒中的融合起始区的功能来预防病毒：细胞融合的方法
- 申请号：EP10182056.1 申请日：2004-11-03
- 公开(公告)号：EP2261378B1 公开(公告)日：2013-10-09
- 发明人： Garry, Robert, F , Wilson, Russell B
- 申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , Autoimmune Technologies, LLC
- 申请人地址： 1430 Tulane Avenue New Orleans, LA 70112-2699 US
- 专利权人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND,Autoimmune Technologies, LLC
- 当前专利权人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND,Autoimmune Technologies, LLC
- 当前专利权人地址： 1430 Tulane Avenue New Orleans, LA 70112-2699 US
- 代理机构： Bassil, Nicholas Charles
- 优先权： US517181P 20031104
- 主分类号： C12Q1/70
- IPC分类号： C12Q1/70 ; C07K16/08 ; C07K14/005 ; C07K7/00 ; A61K38/04 ; A61K38/16 ; A61K39/12 ; A61K39/42 ; G01N33/48 ; G01N33/569
摘要：
The present invention relates to a method of preventing or inhibiting viral infection of a cell and/or fusion between the envelope of a virus and the membranes of a cell targeted by the virus (thereby preventing delivery of the viral genome into the cell cytoplasm, a step required for viral infection). The present invention particularly relates to the families of RNA viruses, including the arenaviruses, coronaviruses, filoviruses, orthomyxoviruses, paramyxoviruses, and retroviruses, having Class I membrane fusion proteins as the fusion proteins that mediate this fusion process. The present invention provides for a method of identifying a conserved motif or domain called the fusion initiation region (FIR) in these viruses. The present invention further provides for methods of preventing infection by such viruses, by interfering with their FIR. The present invention further provides for methods of treatment and prophylaxis of diseases induced by such viruses.
摘要（中）：
本发明涉及预防或抑制病毒的病毒感染和/或病毒包膜与病毒靶向的细胞膜之间的融合的方法（从而防止病毒基因组递送至细胞质， 病毒感染所需的步骤）。 本发明特别涉及RNA病毒家族，包括具有I类膜融合蛋白作为介导该融合过程的融合蛋白的沙粒病毒，冠状病毒，丝状病毒，正粘病毒，副粘病毒和逆转录病毒。 本发明提供了鉴定这些病毒中称为融合起始区（FIR）的保守基元或结构域的方法。 本发明还提供了通过干扰它们的FIR来预防这些病毒感染的方法。 本发明进一步提供了治疗和预防由这些病毒诱发的疾病的方法。