发明公开
EP2219667A2 THOMSEN-FRIEDENREICH DISACCHARIDE MODIFIED IMMUNOGEN (TFD), PREPARATION PROCEDURE, COMPOSITIONS COMPRISING IT, USES, AND TREATMENT METHODS
审中-公开
基本信息:
- 专利标题： THOMSEN-FRIEDENREICH DISACCHARIDE MODIFIED IMMUNOGEN (TFD), PREPARATION PROCEDURE, COMPOSITIONS COMPRISING IT, USES, AND TREATMENT METHODS
- 专利标题（中）：THOMSEN - 弗里德里希糖修饰免疫原（TFD），工艺中，含有组合物，应用和治疗
- 申请号：EP08852281.8 申请日：2008-11-19
- 公开(公告)号：EP2219667A2 公开(公告)日：2010-08-25
- 发明人： IRAZOQUI, Fernando José , SENDRA, Víctor Germán , NORES, Gustavo Alejandro
- 申请人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) , Universidad Nacional De Cordoba , Inis Biotech LLC
- 申请人地址： Av. Rivadavia 1906 piso 3 depto. F Buenos Aires C1033AAJ AR
- 专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet),Universidad Nacional De Cordoba,Inis Biotech LLC
- 当前专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet),Universidad Nacional De Cordoba,Inis Biotech LLC
- 当前专利权人地址： Av. Rivadavia 1906 piso 3 depto. F Buenos Aires C1033AAJ AR
- 代理机构： Bublak, Wolfgang
- 优先权： ARP070105146 20071120
- 国际公布： WO2009066245 20090528
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/385
摘要：
Modified Thomsen-Friedenreich disaccharide (TFD) immunogen, preparation procedure, compositions containing it, uses, and treatment methods. More specif ically, the present invention refers to a immunogen obtained by modifying TFD, and comprising the general formula D-TFD- Lys(n)-C, wherein D is a hydrophobic terminal residue, TFD is disaccharide Galβ3GalNAcα; Lys(n) is a lysine connector, and n is an integer between 1 and 5, and C is a carrier. In a preferred embodiment, the modified invention immunogen comprises the general formula BzlαTFD-Lys5-KLHs, wherein BzI is benzyl, TFD is disaccharide Galβ3GalNAcα; Lys5 is penta-lysine, and KLHs is succinilated Keyhole limpets hemocyanin.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |