基本信息:
- 专利标题： POLYPEPTIDE COMPOUND
- 专利标题（中）：多肽化合物
- 申请号：EP08845535.7 申请日：2008-10-28
- 公开(公告)号：EP2204379A1 公开(公告)日：2010-07-07
- 发明人： TOMISHIMA, Masaki , MORIKAWA, Hiroshi , MAKINO, Takuya , IMANISHI, Masashi , KAYAKIRI, Natsuko , ASANO, Toru , ARAKI, Takanobu , NAKAGAWA, Toshiya
- 申请人： Astellas Pharma Inc.
- 申请人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 代理机构： Gille Hrabal Struck Neidlein Prop Roos
- 优先权： JP2007280446 20071029
- 国际公布： WO2009057568 20090507
- 主分类号： C07K7/56
- IPC分类号： C07K7/56 ; A61K38/00 ; A61P31/10
摘要：
[Problems] To provide an antibacterial agent, particularly a novel polypeptide compound having an antifungal action.
[Means for Solution] As a result of an extensive study on a novel antifungal agent, the inventors have found that an excellent anti-deep-fungal activity is exhibited by introducing a cyclohexylmethylamino group or a piperidylmethylamino group as a partial structure of a natural polypeptide compound, and completed the present invetion.
The compound of the present invetion has an excellent antibacterial activity and is therefore useful as an agent for preventing or treating various fungal infections.
摘要（中）：
[Means for Solution] As a result of an extensive study on a novel antifungal agent, the inventors have found that an excellent anti-deep-fungal activity is exhibited by introducing a cyclohexylmethylamino group or a piperidylmethylamino group as a partial structure of a natural polypeptide compound, and completed the present invetion.
The compound of the present invetion has an excellent antibacterial activity and is therefore useful as an agent for preventing or treating various fungal infections.
[课题]提供抗菌剂，特别是具有抗真菌作用的新型多肽化合物。 [溶液的方法]作为对新型抗真菌剂的广泛研究的结果，发明人已经发现通过引入环己基甲基氨基或哌啶基甲基氨基作为天然多肽的部分结构显示出优异的抗深部真菌活性 化合物，并完成了目前的研究。 本发明化合物具有优异的抗菌活性，因此可用作预防或治疗各种真菌感染的药剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K7/00 | 在完全确定的序列中含有5~20个氨基酸的肽；其衍生物 |
| --------C07K7/04 | .仅含有正常肽键的直链肽 |
| ----------C07K7/54 | ..在环中至少有1个非正常的肽键 |
| ------------C07K7/56 | ...不通过2,4-二氨基丁酸实现环化 |