发明公开
EP2177525A1 METAL COMPLEX COMPOUND, CANCER THERAPEUTIC COMPOSITION COMPRISING THE METAL COMPLEX COMPOUND AS ACTIVE INGREDIENT, AND INTERMEDIATE FOR PRODUCTION OF THE METAL COMPLEX COMPOUND
审中-公开
基本信息:
- 专利标题： METAL COMPLEX COMPOUND, CANCER THERAPEUTIC COMPOSITION COMPRISING THE METAL COMPLEX COMPOUND AS ACTIVE INGREDIENT, AND INTERMEDIATE FOR PRODUCTION OF THE METAL COMPLEX COMPOUND
- 专利标题（中）：金属络合物，癌症治疗的复合体金属络合物用于金属络合物化合物的生产主动和中间体
- 申请号：EP08790864.6 申请日：2008-07-04
- 公开(公告)号：EP2177525A1 公开(公告)日：2010-04-21
- 发明人： EKIMOTO, Hisao
- 申请人： TMRC Co., Ltd.
- 申请人地址： 4-3, Akasaka 3-chome Minato-ku Tokyo 107-0052 JP
- 专利权人： TMRC Co., Ltd.
- 当前专利权人： TMRC Co., Ltd.
- 当前专利权人地址： 4-3, Akasaka 3-chome Minato-ku Tokyo 107-0052 JP
- 代理机构： Jones, Helen M.M.
- 优先权： JP2007179040 20070706; JP2008034907 20080215
- 国际公布： WO2009008345 20090115
- 主分类号： C07F9/24
- IPC分类号： C07F9/24 ; A61K31/664 ; A61P35/00 ; C07F9/40 ; C07F15/00
摘要：
A metal complex compound which exhibits a high degree of adsorption to bone or inhibition of cell growth, and is highly effective for therapy of a cancer metastasized to bone and therapy of the primary carcinoma thereof; a therapeutic agent composition for a cancer containing as an active ingredient the metal complex compound or a physiologically acceptable salt thereof; and an intermediate for the metal complex compound are provided. More concretely, a metal complex compound represented by the following General Formula (1):
(wherein R 1 independently represents C 1 -C 10 alkyl which may be branched or have a substituent; or a C 3 -C 30 cyclic group which may have a substituent; and X represents CHR 2 , an oxygen atom or NR 5 );
a therapeutic agent composition for a cancer containing it as an active ingredient; and an intermediate for the metal complex compound are provided.
摘要（中）：
(wherein R 1 independently represents C 1 -C 10 alkyl which may be branched or have a substituent; or a C 3 -C 30 cyclic group which may have a substituent; and X represents CHR 2 , an oxygen atom or NR 5 );
a therapeutic agent composition for a cancer containing it as an active ingredient; and an intermediate for the metal complex compound are provided.
的金属配合物化合物，其表现出高程度吸附到骨或细胞生长的抑制的，并且是用于转移至骨和其原发癌的治疗癌症的治疗非常有效的; 对于含有作为活性成分的金属配位化合物或其生理学上可接受的盐的癌症的治疗剂组合物; 和在中间的金属配位化合物中提供。 更具体地，金属配位化合物由下述通式（1）：（其中R 1独立地darstellt C 1 -C 10烷基可以是支链或具有一个取代基;或C 3 -C 30环状基团可以具有 的取代基;和X darstellt CHR 2中，在氧原子或NR 5）; 对于含有它作为活性成分的癌症的治疗剂组合物; 和在中间的金属配位化合物中提供。