基本信息:
- 专利标题： INCREASED EFFECTIVENESS OF ALLYLAMINE DRUG COMPOUNDS
- 专利标题（中）：烯丙基胺补救联系提高效力
- 申请号：EP08725165.8 申请日：2008-02-05
- 公开(公告)号：EP2124878B1 公开(公告)日：2015-09-02
- 发明人： SUVANPRAKORN, Pichit , ZAIAS, Nardo , VAYUMHASUWAN, Panida
- 申请人： Biophile Corporation, Ltd
- 申请人地址： 884-886 Ploenchit Road Lumpinee Patumwan Bankok 10330 TH
- 专利权人： Biophile Corporation, Ltd
- 当前专利权人： Biophile Corporation, Ltd
- 当前专利权人地址： 884-886 Ploenchit Road Lumpinee Patumwan Bankok 10330 TH
- 代理机构： Johnson, Yvonne Catherine
- 优先权： US899433P 20070205
- 国际公布： WO2008097530 20080814
- 主分类号： A61K31/131
- IPC分类号： A61K31/131 ; A61K31/137 ; A61P31/10 ; A61K47/10 ; A61K47/24 ; A61K47/26 ; A61K9/127 ; A61K9/50
摘要：
The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages The allylamine active ingredient is prepared in an acidic environment, which alters the physiochemical properties of the active ingredient resulting in the ingredient having a positive charge The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.
公开/授权文献:
- EP2124878A1 INCREASED EFFECTIVENESS OF ALLYLAMINE DRUG COMPOUNDS 公开/授权日：2009-12-02
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/131 | ..无环的 |