基本信息:
- 专利标题： AUTOMATABLE ARTIFICIAL IMMUNE SYSTEM (AIS)
- 专利标题（中）：自动化仪器仪表（AIS）
- 申请号：EP07753216.6 申请日：2007-03-15
- 公开(公告)号：EP2007878A2 公开(公告)日：2008-12-31
- 发明人： WARREN, William, L. , PARKHILL, Robert , NGUYEN, Michael, N. , SANCHEZ-SCHMITZ, Guzman , FAHLENKAMP, Heather , HIGBEE, Russell , DRAKE, Donald, III , KACHURIN, Anatoly, M. , MOE, David
- 申请人： VaxDesign Corporation
- 申请人地址： 12612 Challenger Parkway, Suite 365 Orlando, FL 32826 US
- 专利权人： VaxDesign Corporation
- 当前专利权人： VaxDesign Corporation
- 当前专利权人地址： 12612 Challenger Parkway, Suite 365 Orlando, FL 32826 US
- 代理机构： Griffin, Philippa Jane
- 优先权： US375033 20060315
- 国际公布： WO2007106575 20070920
- 主分类号： C12N5/06
- IPC分类号： C12N5/06 ; G01N33/50
摘要：
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. In particular the claimed artificial immune system comprises a vaccination site, comprising a first matrix and a plurality of cells attached to said matrix, wherein a plurality of said vaccination sites are organized in a multi-well format; and a three-dimensional artificial lymphoid tissue, comprising a second matrix and a plurality of lymphocytes and leukocytes, wherein a plurality of said three-dimensional artificial lymphoid tissues are organized in a second multi-well format. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interactions with the immune system.
摘要（中）：
本发明涉及构建综合人造免疫系统的方法，其包括适当的体外细胞和组织构建体或其等同物以模拟与哺乳动物中的疫苗相互作用的正常组织。 人造免疫系统可用于测试疫苗候选物在体外的功效，因此可用于加速疫苗开发和测试与免疫系统的药物和化学相互作用。