基本信息:
- 专利标题： METHOD FOR PRODUCING CARBOXYLIC ACID COMPOUND
- 专利标题（中）：VERFAHREN ZUR HERSTELLUNG EINERCARBONSÄUREVERBINDUNG
- 申请号：EP07740249.3 申请日：2007-03-29
- 公开(公告)号：EP2003112A1 公开(公告)日：2008-12-17
- 发明人： KATSURADA, Manabu , NAKAJIMA, Yasuko , KASUGA, Yuzo , ONOGI, Kazuhiro , ODA, Toshiaki
- 申请人： Kowa Company, Ltd.
- 申请人地址： 6-29, Nishiki 3-chome Naka-ku Nagoya-shi, Aichi-ken 460-8625 JP
- 专利权人： Kowa Company, Ltd.
- 当前专利权人： Kowa Company, Ltd.
- 当前专利权人地址： 6-29, Nishiki 3-chome Naka-ku Nagoya-shi, Aichi-ken 460-8625 JP
- 代理机构： Polypatent
- 优先权： JP2006096334 20060331
- 国际公布： WO2007114223 20071011
- 主分类号： C07C51/373
- IPC分类号： C07C51/373 ; C07C49/233 ; C07C59/56 ; C07C69/738 ; C07C45/65 ; C07C51/353 ; C07C51/367 ; C07C59/88 ; C07C67/313 ; C07C67/343
摘要：
A method for conveniently preparing 2,2-dichloro-12-(4-chlorophenyl)-10-hydroxydodecanoic acid useful as an active ingredient of therapeutic agents for diseases such as diabetes at a high yield, which comprises the step of reacting a compound represented by the following general formula (A):
wherein X represents a halogen atom, and a compound represented by the following general formula (B): CHCl 2 COOR 1 wherein R 1 represents hydrogen atom or a protective group of carboxyl group, to prepare a compound represented by the following general formula (C):
wherein R 1 has the same meaning as that defined above.
摘要（中）：
wherein X represents a halogen atom, and a compound represented by the following general formula (B): CHCl 2 COOR 1 wherein R 1 represents hydrogen atom or a protective group of carboxyl group, to prepare a compound represented by the following general formula (C):
wherein R 1 has the same meaning as that defined above.
方便地制备用作高收率糖尿病等治疗剂的活性成分的2,2-二氯-12-（4-氯苯基）-10-羟十二酸的方法，该方法包括使代表的化合物 由下列通式（A）表示：其中X表示卤素原子，和由下列通式（B）表示的化合物：其中R 1表示氢原子或羧基保护基的CHCl 2 COOR 1，以制备 由以下通式（C）表示的化合物：其中R 1具有与上述相同的含义。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C51/00 | 羧酸或它们的盐、卤化物或酐的制备 |
| --------C07C51/347 | .不包括形成羧基的反应 |
| ----------C07C51/373 | ..引入仅以双键连接的含氧官能团 |