基本信息:
- 专利标题： INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING
- 专利标题（中）：VEGF受体和HGF受体信号的抑制剂
- 申请号：EP06851548.5 申请日：2006-05-19
- 公开(公告)号：EP1957498A2 公开(公告)日：2008-08-20
- 发明人： SAAVEDRA, Oscar, Mario , CLARIDGE, Stephen, William , ZHAN, Lijie , RAEPPEL, Franck , VAISBURG, Arkadii , RAEPPEL, Stephane , DEZIEL, Robert , MANNION, Michael , ZHOU, Nancy , GAUDETTE, Frederic , ISAKOVIC, Ljubomir , WAHHAB, Amal , GRANGER, Marie-Claude , BERNSTEIN, Naomy
- 申请人： MethylGene Inc.
- 申请人地址： 7220 Frederick-Banting St. Laurent, QC H4S 2A1 CA
- 专利权人： MethylGene Inc.
- 当前专利权人： MIRATI THERAPEUTICS, INC.
- 当前专利权人地址： MIRATI THERAPEUTICS, INC.
- 代理机构： Schnappauf, Georg
- 优先权： US683036P 20050520; US754902P 20051229; US785054P 20060322
- 国际公布： WO2008041053 20080410
- 主分类号： C07D495/04
- IPC分类号： C07D495/04
摘要：
The invention relates to compounds of formula A, and their use for inhibiting the VEGF receptor KDR and the HGF receptor c-met Pn preferred structures of formula A, A
1 is S, A
2 =A
3 =CH, Z is O, S, S(O)
0-2 or NR
5 , Ar is phenyl, and G includes a nitrogen linker to Ar The groups D, G, and R
5 are as defined herein The invention also provides compositions and methods for treating cell proliferative diseases and conditions Examples of the diseases include breast cancer, lung cancer, colon cancer, rectal cancer, bladder cancer, leukemia and renal
摘要（中）：
1 is S, A
2 =A
3 =CH, Z is O, S, S(O)
0-2 or NR
5 , Ar is phenyl, and G includes a nitrogen linker to Ar The groups D, G, and R
5 are as defined herein The invention also provides compositions and methods for treating cell proliferative diseases and conditions Examples of the diseases include breast cancer, lung cancer, colon cancer, rectal cancer, bladder cancer, leukemia and renal
本发明涉及式A化合物及其用于抑制式A的VEGF受体KDR和HGF受体c-met P n优选结构的用途，A 1是S，A 2 = A 3 = CH，Z是O，S ，S（O）0-2或NR 5，Ar为苯基，并且G包括与Ar连接的氮连接基团D，G和R 5如本文所定义。本发明还提供了用于治疗细胞增殖性疾病的组合物和方法，和 病症的例子包括乳腺癌，肺癌，结肠癌，直肠癌，膀胱癌，白血病和肾
公开/授权文献:
- EP1957498B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING 公开/授权日：2017-02-15
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D495/00 | 杂环化合物，在稠环系中至少有1个杂环具有硫原子作为仅有的杂环原子 |
| --------C07D495/02 | .在稠环系中含有两个杂环 |
| ----------C07D495/04 | ..邻位稠合系 |