基本信息:
- 专利标题： KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF
- 专利标题（中）：和激肽受体B1 PEPTIDAGONISTE及其用途
- 申请号：EP06741590.1 申请日：2006-05-31
- 公开(公告)号：EP1937710A1 公开(公告)日：2008-07-02
- 发明人： GOBEIL, Fernand, Jr. , NEUGEBAUER, Witold, A. , REGOLI, Domenico , FORTIN, David
- 申请人： Université de Sherbrooke
- 申请人地址： 2500, boul. de l'Université Sherbrooke, Québec J1K 2R1 CA
- 专利权人： Université de Sherbrooke
- 当前专利权人： SOCPRA SCIENCES SANTE ET HUMAINES S.E.C.
- 当前专利权人地址： SOCPRA SCIENCES SANTE ET HUMAINES S.E.C.
- 代理机构： Fleuchaus, Michael A.
- 优先权： US685886P 20050601
- 国际公布： WO2006128293 20061207
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; A61P9/00 ; A61K38/08 ; A61P31/08 ; A61P35/00 ; A61P9/02
摘要：
The present invention provides for novel kinin B1 receptors peptide agonists of formula (I) having very good to excellent affinities and selectivity for the B1 receptor, in vitro and in vivo increased resistance to enzymatic degradation, superior pharmacokinetic properties to those of naturally occurring agents, capacity to significantly enhance delivery of chemotherapeutic substances across the blood brain barrier and within peripheral tissues for the treatment of tumors, capacity to protect and restore kidney, heart, brain and other organ functions, when given alone or in combination with other therapies in the treatment of hypertension, diabetes and other cardiovascular diseases particularly, but not limited to, atherosclerosis and arteriosclerosis. Formula (I): aay-aax-aa0-aa1-aa2-aa3-aa4-aa5-Ser6-Pro7-D-Phe8-X.
公开/授权文献:
- EP1937710B1 KININ B1 RECEPTOR PEPTIDE AGONISTS AND USES THEREOF 公开/授权日：2012-10-17
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K7/00 | 在完全确定的序列中含有5~20个氨基酸的肽；其衍生物 |
| --------C07K7/04 | .仅含有正常肽键的直链肽 |
| ----------C07K7/06 | ..含有5~11个氨基酸 |