基本信息:
- 专利标题： SPECIFIC BINDING SITES IN COLLAGEN FOR INTEGRINS AND USE THEREOF
- 专利标题（中）：特异结合位点的胶原蛋白及其使用和整合
- 申请号：EP06772177.9 申请日：2006-06-05
- 公开(公告)号：EP1889062A2 公开(公告)日：2008-02-20
- 发明人： HOOK, Magnus
- 申请人： THE TEXAS A & M UNIVERSITY SYSTEM
- 申请人地址： 3369 Tamu College Station, TX 77843-3369 US
- 专利权人： THE TEXAS A & M UNIVERSITY SYSTEM
- 当前专利权人： THE TEXAS A & M UNIVERSITY SYSTEM
- 当前专利权人地址： 3369 Tamu College Station, TX 77843-3369 US
- 代理机构： Heaton, Joanne Marie
- 优先权： US687432P 20050603
- 国际公布： WO2006133107 20061214
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.