基本信息:
- 专利标题： METHODS AND MATERIALS FOR ASSESSING PROSTATE CANCER THERAPIES
- 专利标题（中）：方法和材料前列腺癌症治疗的评价
- 申请号：EP04814409.1 申请日：2004-12-16
- 公开(公告)号：EP1709193A2 公开(公告)日：2006-10-11
- 发明人： SAWYERS, Charles,L. , CHEN, Charlie D. , WELSBIE, Derek
- 申请人： The Regents of the University of California
- 申请人地址： 12th Floor, 1111 Franklin Street Oakland, California 94607-5200 US
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： 12th Floor, 1111 Franklin Street Oakland, California 94607-5200 US
- 代理机构： Campbell, Patrick John Henry
- 优先权： US531091P 20031219
- 国际公布： WO2005060661 20050707
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; A01N43/04 ; A61K31/70
摘要：
Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest (2-5 fold) increase in androgen receptor (AR) mRNA was the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides insight toward the design of novel antiandrogens.