发明公开
EP1705177A1 N-aryl-sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents
审中-公开
基本信息:
- 专利标题： N-aryl-sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents
- 专利标题（中）：N-芳基取代的嘧啶作为亚磺酰亚胺和CDK的VEGF抑制剂，它们的制备和作为药物的用途
- 申请号：EP05090073.7 申请日：2005-03-23
- 公开(公告)号：EP1705177A1 公开(公告)日：2006-09-27
- 发明人： Lücking, Ulrich, Dr. , Siemeister, Gerhard , Jautelat, Rolf
- 申请人： Schering Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13342 Berlin DE
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13342 Berlin DE
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D239/47 ; A61K31/505 ; A61P35/00 ; C07C381/10
摘要：
This invention relates to pyrimidine derivatives of general formula (I)
in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
摘要（中）：
in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
本发明涉及其中Q，R1，R2，R3，R4，R5，X和m的通式（I）的嘧啶衍生物的含义也被包含在本说明书中，如细胞周期蛋白依赖性激酶和VEGF的抑制剂 受体酪氨酸激酶，它们的制备，以及它们作为药物使用用于治疗各种疾病。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D239/00 | 杂环化合物，含1,3-二嗪环或氢化1,3-二嗪环 |
| --------C07D239/02 | .不与其他环稠合 |
| ----------C07D239/06 | ..环原子间或环原子与非环原子间有1个双键 |
| ------------C07D239/28 | ...有杂原子或有以3个键连杂原子、其中最多以1个键连卤素的碳原子，直接连在环碳原子上 |
| --------------C07D239/32 | ....1个氧、硫或氮原子 |
| ----------------C07D239/48 | .....两个氮原子 |