
基本信息:
- 专利标题: SUBSTITUTED BENZYLAMINOALKYLENE HETEROCYCLES
- 专利标题(中):取代BENZYLAMINOALKYLENHETEROCYCLEN
- 申请号:EP04790126.9 申请日:2004-10-05
- 公开(公告)号:EP1673356B1 公开(公告)日:2012-04-11
- 发明人: SALVATI, Patricia , CACCIA, Carla , MELLONI, Piero , RESTIVO, Alessandra , SABIDO DAVID, Cibele , VALLESE, Stefania, Nikem
- 申请人: Newron Pharmaceuticals S.p.A.
- 申请人地址: Via L. Ariosto, 21 20091 Bresso (MI) IT
- 专利权人: Newron Pharmaceuticals S.p.A.
- 当前专利权人: Newron Pharmaceuticals S.p.A.
- 当前专利权人地址: Via L. Ariosto, 21 20091 Bresso (MI) IT
- 代理机构: Minoja, Fabrizio
- 优先权: EP03023342 20031015
- 国际公布: WO2005040138 20050506
- 主分类号: C07D261/02
- IPC分类号: C07D261/02 ; C07D307/14 ; C07D307/38 ; C07D319/12 ; C07D213/38 ; C07D233/54 ; C07D249/02 ; C07D277/10 ; C07D327/04 ; C07D333/20 ; C07D307/81 ; C07D235/14 ; A61K31/341 ; A61K31/422 ; A61K31/426
摘要:
This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one or more fluoro, chloro, trifluoromethyl, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy; R2, R3 are independently hydrogen, C1-C6 alkyl, halogen, trifluoromethyl, hydroxy or C1-C6 alkoxy; R4 is hydrogen, C1-C8 alkyl; R5, R6 are independently hydrogen, C1-C3 alkyl, optionally substituted by hydroxy or phenyl; R7 is hydrogen or straight or branched C1-C3 alkyl; Het is a five to seven membered, saturated or unsaturated heteromonocyclic or an eight to ten membered, saturated or unsaturated heterobicyclic group, containing one or more heteroatoms chosen independently from nitrogen, oxygen and sulphur, said mono- or bicyclic groups being optionally substituted by C1-C6alkyl, halogen, hydroxyl or C1-C6 alkoxy; and the pharmaceutically acceptable salts or prodrug thereof, that are active as sodium and/or calcium channel modulators and/or as selective MAO-B inhibitors and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
公开/授权文献:
- EP1673356A1 SUBSTITUTED BENZYLAMINOALKYLENE HETEROCYCLES 公开/授权日:2006-06-28
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D261/00 | 杂环化合物,含有1,2-唑环或氢化1,2-唑环 |
--------C07D261/02 | .不与其他环稠合 |