发明公开
EP1633352A1 POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN
有权
基本信息:
- 专利标题： POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN
- 专利标题（中）：POLYENOXAZOLE具有抗肿瘤效应AND METHOD FOR THE PRODUCTION BY链霉菌的菌株来
- 申请号：EP04737813.8 申请日：2004-06-14
- 公开(公告)号：EP1633352A1 公开(公告)日：2006-03-15
- 发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
- 申请人： Ecopia Biosciences Inc.
- 申请人地址： 7290 Frederick-Banting Saint-Laurent, QC H4S 2A1 CA
- 专利权人： Ecopia Biosciences Inc.
- 当前专利权人： Ecopia Biosciences Inc.
- 当前专利权人地址： 7290 Frederick-Banting Saint-Laurent, QC H4S 2A1 CA
- 代理机构： Vossius & Partner
- 优先权： US477931P 20030613
- 国际公布： WO2004110439 20041223
- 主分类号： A61K31/422
- IPC分类号： A61K31/422 ; C07D413/12 ; A61K31/421 ; C07D263/32 ; C12P17/16 ; C12R1/60 ; A61P35/00
摘要：
This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/42 | ....口恶唑 |
| ----------------A61K31/422 | .....未稠合的并含有另外的杂环的 |