基本信息:
- 专利标题： PYRAZOLES AND METHODS OF MAKING AND USING THE SAME
- 专利标题（中）：吡唑和其生产和使用
- 申请号：EP04710613.3 申请日：2004-02-12
- 公开(公告)号：EP1596656A2 公开(公告)日：2005-11-23
- 发明人： LEE, Wen-Cherng , SUN, Lihong , SHAN, Feng , CHUAQUI, Claudio , CORNEBISE, Mark , PONTZ, Timothy, W. , CARTER, Marybeth , SINGH, Juswinder , BORIACK-SJODIN, Paula, Ann , LING, Leona , PETTER, Russell, C.
- 申请人： Biogen Idec MA Inc.
- 申请人地址： 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 专利权人： Biogen Idec MA Inc.
- 当前专利权人： Biogen Idec MA Inc.
- 当前专利权人地址： 14 Cambridge Center Cambridge, Massachusetts 02142 US
- 代理机构： Adams, Harvey Vaughan John
- 优先权： US446777P 20030212
- 国际公布： WO2004072033 20040826
- 主分类号： A01N43/58
- IPC分类号： A01N43/58 ; A01N43/60 ; A01N43/42 ; A01N43/40 ; A61K31/54 ; A61K31/501 ; A61K31/495 ; A61K31/497 ; A61K31/47 ; A61K31/50 ; A61K31/4965 ; A61K31/44
摘要：
The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).