基本信息:
- 专利标题： METHOD FOR SUPPRESSING IMMUNE SYSTEM RESPONSE TO TRANSPLANTED TISSUE OR CELLS
- 专利标题（中）：程序减少免疫反应反对组织或细胞移植
- 申请号：EP03783222.7 申请日：2003-11-07
- 公开(公告)号：EP1578958A2 公开(公告)日：2005-09-28
- 发明人： EDELSON, Richard Leslie , BERGER, Carole , GIRARDI, Michael
- 申请人： Yale University School of Medicine
- 申请人地址： 333 Cedar Street New Haven, Connecticut 06510 US
- 专利权人： Yale University School of Medicine
- 当前专利权人： Yale University School of Medicine
- 当前专利权人地址： 333 Cedar Street New Haven, Connecticut 06510 US
- 代理机构： Vorberg, Jens
- 优先权： US290802 20021108
- 国际公布： WO2004044149 20040527
- 主分类号： C12N5/06
- IPC分类号： C12N5/06
摘要：
Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The maturation of the dendritic cells is truncated at a stage where the dendritic cells can inactivate T cell clones which would otherwise generate an undesired immune system response. The immature dendritic cells can be directly administered to the transplant recipient, or the dendritic cells can be co-incubated with the bone marrow or stem cell preparation, prior to transplantation, in order to suppress or eliminate anti-recipient donor T cells contaminating the bone marrow or stem cell preparation. The methods can be used to suppress graft versus host disease in recipients of transplanted bone marrow or stem cells, or to suppress rejection of transplanted organs or tissue.