
基本信息:
- 专利标题: SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY
- 专利标题(中):SICHERE CHEMISCHE ENTKUPPLER ZUR BEHANDLUNG VON FETTSUCHT
- 申请号:EP03810374.3 申请日:2003-10-31
- 公开(公告)号:EP1575575A2 公开(公告)日:2005-09-21
- 发明人: HANSEN, Birgit, Sehested , TULLIN, Soren , HANSEN, Thomas, Kruse , COLDING-JORGENSEN, Morten
- 申请人: NOVO NORDISK A/S
- 申请人地址: Novo Allé 2880 Bagsvaerd DK
- 专利权人: NOVO NORDISK A/S
- 当前专利权人: NOVO NORDISK A/S
- 当前专利权人地址: Novo Allé 2880 Bagsvaerd DK
- 优先权: DK200201719 20021108; DK200300734 20030514; DK200300827 20030604
- 国际公布: WO2004041256 20040521
- 主分类号: A61K31/04
- IPC分类号: A61K31/04
摘要:
This invention relates to chemical uncouplers with a broader safety window making the use of them in treating obesity and, consequently, in the treatment of obesity related dis-eases and conditions such as atherosclerosis, hypertension, diabetes, especially type 2 dia-betes (NIDDM (non-insulin dependent diabetes mellitus)), impaired glucose tolerance, dyslip-idemia, coronary heart disease, gallbladder disease, osteoarthritis and various types of can-cer such as endometrial, breast, prostate and colon cancers and the risk for premature death as well as other conditions, such as diseases and disorders, which conditions are improved by an increase in mitochondrial respiration, more attractive.
摘要(中):
本发明涉及具有更广泛安全窗口的化学解偶联剂,其使用它们来治疗肥胖症,因此用于治疗肥胖相关疾病和病症如动脉粥样硬化,高血压,糖尿病,特别是2型糖尿病(NIDDM(非胰岛素 依赖性糖尿病)),葡萄糖耐量异常,血脂异常,冠心病,胆囊疾病,骨关节炎和各种类型的癌症如子宫内膜癌,乳腺癌,前列腺癌和结肠癌以及过早死亡的风险以及其他病症如疾病 和疾病,通过线粒体呼吸的增加改善了这些病症,更有吸引力。
公开/授权文献:
- EP1575575B1 SAFE CHEMICAL UNCOUPLERS FOR THE TREATMENT OF OBESITY 公开/授权日:2010-05-19
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/04 | .硝基化合物 |