基本信息:
- 专利标题： SELF-ASSEMBLING RECOMBINANT HPV16 PAPILLOMAVIRUS CAPSID PROTEINS
- 专利标题（中）：自组装的衣壳蛋白的重组HPV16 FROM乳头瘤病毒
- 申请号：EP04104531.1 申请日：1993-09-03
- 公开(公告)号：EP1538209A3 公开(公告)日：2008-02-20
- 发明人： Lowy, Douglas R , Schiller, John T , Kirnbauer, Reinhard
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： The National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852 US
- 代理机构： Bizley, Richard Edward
- 优先权： US941371 19920903; US32869 19930316
- 主分类号： C12N15/37
- IPC分类号： C12N15/37 ; C12N7/04 ; C12N15/86 ; C12N5/10 ; A61K39/12 ; G01N33/53 ; C07K14/025
摘要：
Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.