基本信息:
- 专利标题： COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
- 专利标题（中）：埃博霉素含组合及其药物用途
- 申请号：EP03757040.5 申请日：2003-06-06
- 公开(公告)号：EP1515750A1 公开(公告)日：2005-03-23
- 发明人： HOHNEKER, John, Arthur , MILLER, Julie, Ann , ROTHERMEL, John, David , WARTMANN, Markus
- 申请人： Novartis AG , Novartis Pharma GmbH
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG,Novartis Pharma GmbH
- 当前专利权人： Novartis AG,Novartis Pharma GmbH
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： de Weerd, Petrus G.W.
- 优先权： US387025P 20020610; US406238P 20020827; US406239P 20020827; US438677P 20030108; US438676P 20030108
- 国际公布： WO2003103712 20031218
- 主分类号： A61K45/06
- IPC分类号： A61K45/06 ; A61K39/395 ; A61K31/426 ; A61K31/427 ; A61P35/00
摘要：
The invention relates to a pharmaceutical combination which comprises (a) a HER-1 or a HER-2 antibody or (b) at least one antineoplastic agent selected from the group consisting of aromatase inhibitors, antiestrogens, topoisomerase I inhibitors, topoisomerase II inhibitors, microtubule active agents, protein kinase C inhibitors, anti-angiogenic compounds, gonadorelin agonists, anti-androgens, histone deacetylase inhibitors and S-adenosyl-methionine decarboxylase inhibitors; and (c) an epothilone derivative of formula (I), and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular, for the treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition comprising such a combination; the use of such a combination for the preparation of a medicament for the treatment of a proliferative disease; a commercial package or product comprising such a combination as a combined preparation for simultaneous, separate or sequential use; and to a method of treatment of a warm-blooded animal, especially a human.
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K45/00 | 在A61K31/00至A61K41/00各组中不包含的含有效成分的医用配制品 |
| --------A61K45/06 | .无化学特性之有效成分的混合物，例如消炎药和强心剂 |