基本信息:
- 专利标题： PEPTIDES AND RELATED MOLECULES THAT BIND TO TALL-1
- 专利标题（中）：肽和相关分子，为TALL-1结合
- 申请号：EP02769739.0 申请日：2002-05-13
- 公开(公告)号：EP1385882A2 公开(公告)日：2004-02-04
- 发明人： MIN, Hosung , HSU, Hailing , XIONG, Fei
- 申请人： Amgen, Inc.
- 申请人地址： One Amgen Center Drive Thousands Oaks, CA 91320-1799 US
- 专利权人： Amgen, Inc.
- 当前专利权人： Amgen, Inc.
- 当前专利权人地址： One Amgen Center Drive Thousands Oaks, CA 91320-1799 US
- 代理机构： Richardson, Kate
- 优先权： US290196P 20010511
- 国际公布： WO2002092620 20021121
- 主分类号： C07K14/52
- IPC分类号： C07K14/52 ; C07K14/525 ; A61K38/19 ; C12N5/10 ; C12N15/28
摘要：
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae a?1a2a3CDa6La8a9a10Ca12a13a14¿ (SEQ.ID.NO:100), b?1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18¿ (SEQ.ID.NO:104) c?1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18¿ (SEQ.ID.NO:105) d?1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18¿ (SEQ.ID.NO:106) e?1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18¿ (SEQ.ID.NO:107) f?1f2f3Kf5Df7Lf9f10Qf12f13f14¿ (SEQ.ID NO:109) wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
公开/授权文献:
- EP1385882B9 PEPTIDES AND RELATED MOLECULES THAT BIND TO TALL-1 公开/授权日：2009-08-12
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/415 | .来自植物 |
| ----------C07K14/52 | ..细胞激活素；淋巴激活素；干扰素 |