基本信息:
- 专利标题： 3-SUBSTITUTED UREA DERIVATIVES AND MEDICINAL USE THEREOF
- 专利标题（中）：3 - 取代脲衍生物及其医药用途
- 申请号：EP01955657 申请日：2001-08-10
- 公开(公告)号：EP1308438A4 公开(公告)日：2005-09-28
- 发明人： ISHIBUCHI SEIGO , SUMICHIKA HIROSHI , ITOH KATSUHIKO , NAKA YOICHI
- 申请人： MITSUBISHI PHARMA CORP
- 专利权人： MITSUBISHI PHARMA CORP
- 当前专利权人： MITSUBISHI PHARMA CORP
- 优先权： JP2000243290 2000-08-10
- 主分类号： A61K31/17
- IPC分类号： A61K31/17 ; A61P9/10 ; A61P11/00 ; A61P11/06 ; A61P17/02 ; A61P17/06 ; A61P25/28 ; A61P31/04 ; A61P31/12 ; A61P37/06 ; A61P37/08 ; C07C275/28 ; C07C275/30 ; C07C275/34 ; C07C275/40 ; C07C275/42 ; C07C323/43 ; C07C323/44 ; C07D209/14 ; C07D213/64 ; C07D231/12 ; C07D295/135 ; C07D317/58 ; C07D401/06 ; C07D295/12
摘要：
Urea derivatives represented by the following general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein each symbol is as defined in the description. Because of having a C5a receptor antagonism, these compounds are useful as remedies and preventives for diseases or syndromes induced by C5a [for example, autoimmune diseases such as rheumatism and systemic lupus erythematosus, allergic diseases such as sepsis, adult respiratory distress syndrome, chromic obstructive pulmonary disease and asthma, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injuries by the activation of leucocytes caused by ischemia, trauma, burn, surgical invasion, etc. (for example, pneumonia, nephritis, hepatitis and pancreatitis)]. Moreover, these compounds are useful as remedies and preventives for bacterial and viral infections mediated by C5a receptor.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/17 | ..含NC（O）N或NC（S）N基团的，例如尿素、硫脲、卡氮芥 |