发明公开
EP1238069A2 ANTISENSE OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (MGLUR1)
审中-公开
基本信息:
- 专利标题： ANTISENSE OLIGONUCLEOTIDES FOR METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 (MGLUR1)
- 专利标题（中）：反义寡核苷酸FÜRmGluR1
- 申请号：EP00945507.2 申请日：2000-07-17
- 公开(公告)号：EP1238069A2 公开(公告)日：2002-09-11
- 发明人： FUNDYTUS, Marian, E. , CODERRE, Terence, J. , COHEN, S., Robin , HENRY, James, L. , VAINIO, Anneli
- 申请人： McGill University
- 申请人地址： 3550 University Street Montreal,Quebec H3A 2A7 CA
- 专利权人： McGill University
- 当前专利权人： McGill University
- 当前专利权人地址： 3550 University Street Montreal,Quebec H3A 2A7 CA
- 代理机构： Khoo, Chong-Yee
- 优先权： US144004P 19990715
- 国际公布： WO01005963 20010125
- 主分类号： C12N15/11
- IPC分类号： C12N15/11
摘要：
The present invention relates to antisense oligonucleotides for metabotropic glutamate receptor type 1 (mGluR1). There is provided oligonucleotides that hybridize to a mRNA encoding mGluR1 or a splice variant thereof. There is also provided a method for treating a patient having a disorder related to an elevated glutamate level, such as chronic pain, or to enhance an opioid effect or to reduce opioid dependence and/or tolerance, which comprises the administration of such an oligonucleotide. Specific pain treatment is thereby obtained.