基本信息:
- 专利标题： INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK)
- 专利标题（中）：c-Jun N末端激酶的抑制剂（JNK）
- 申请号：EP00926272.6 申请日：2000-04-21
- 公开(公告)号：EP1175399B1 公开(公告)日：2009-03-11
- 发明人： SALITURO, Francesco, Gerald , BEMIS, Guy, W. , WILKE, Susanne , GREEN, Jeremy , CAO, Jingrong , GAO, Huai , HARRINGTON, Edmund, Martin
- 申请人： VERTEX PHARMACEUTICALS INCORPORATED
- 申请人地址： 130 Waverly Street Cambridge, MA 02139-4242 US
- 专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人： VERTEX PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： 130 Waverly Street Cambridge, MA 02139-4242 US
- 代理机构： Vossius & Partner
- 优先权： US130752P 19990423
- 国际公布： WO2000064872 20001102
- 主分类号： C07D209/40
- IPC分类号： C07D209/40 ; A61K31/395 ; A61P43/00 ; C07D413/06 ; C07D405/06 ; C07D417/06 ; C07D401/06 ; C07D403/06 ; C07D409/04 ; C07D409/14 ; C07D405/14 ; C07D417/14 ; C07D401/14 ; C07F7/10
摘要：
The present invention relates to compounds of formula (I) or (II), or a pharmaceutically acceptable derivative or prodrug thereof; wherein Y is selected from -(CH2)-Q1; -(CO)-Q1; -(CO)NH-Q1; -(CO)-O-Q1; -(SO2)-Q1 or -(SO2)NH-Q1; Q1 is a C1-C6 straight chain or branched alkyl or alkenyl group; a 5-7 membered aromatic or non-aromatic carbocyclic or heterocyclic ring; or a 9-14 membered bicyclic or tricyclic aromatic or non-aromatic carbocyclic or heterocyclic ring system, W is N or C; Z is CH or N, which are inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
公开/授权文献:
- EP1175399A1 INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) 公开/授权日：2002-01-30
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D209/00 | 杂环化合物，含五元环、与其他环稠合、带1个氮原子作为惟一的杂环原子 |
| --------C07D209/02 | .与一个碳环稠合 |
| ----------C07D209/04 | ..吲哚；氢化吲哚 |
| ------------C07D209/10 | ...有被杂原子取代的烃基，直接连在杂环的碳原子上 |
| --------------C07D209/40 | ....非硝基氮原子基团，例如，靛红半卡巴腙 |