基本信息:
- 专利标题： Hepatitis b surface antigen particles
- 专利标题（中）：乙型肝炎表面抗原的颗粒
- 申请号：EP00121167.1 申请日：1988-06-22
- 公开(公告)号：EP1088830A3 公开(公告)日：2004-04-07
- 发明人： Thoma, Hans A.
- 申请人： MEDEVA HOLDINGS B.V.
- 申请人地址： Churchill-Laan 223 1078 ED Amsterdam NL
- 专利权人： MEDEVA HOLDINGS B.V.
- 当前专利权人： MEDEVA HOLDINGS B.V.
- 当前专利权人地址： Churchill-Laan 223 1078 ED Amsterdam NL
- 代理机构： Campbell, Patrick John Henry
- 优先权： EP87108914 19870622; EP87108915 19870622
- 主分类号： C07K14/02
- IPC分类号： C07K14/02 ; A61K39/29 ; C12N15/40 ; A61P31/14
摘要：
The invention provides an immunogenic particle comprising a plurality of copies of a first peptide monomer, said peptide monomer comprising a first discrete region and a second discrete region, said first region comprising an HBV pre-S 1 epitope and said second region comprising a peptide which upon secretion will direct formation of particles that will provoke an immune response against the pre-S 1 epitope, wherein said first peptide monomer constitutes more than five percent of all the protein in the particle and said particle is free of pre-S 1 peptide. The particle is useful in the preparation of vaccines against hepatitis B virus.
公开/授权文献:
- EP1088830A2 Hepatitis b surface antigen particles 公开/授权日：2001-04-04
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/005 | .来自病毒 |
| ----------C07K14/01 | ..DNA病毒 |
| ------------C07K14/02 | ...Hepadnavridae，例如，B肝病毒 |