基本信息:
- 专利标题： REVERSE-TURN MIMETICS AND METHODS RELATING THERETO
- 专利标题（中）：反向转角模拟物和相关程序
- 申请号：EP98918829.7 申请日：1998-04-28
- 公开(公告)号：EP0980373A1 公开(公告)日：2000-02-23
- 发明人： KAHN, Michael, S. , EGUCHI, Masakatsu , KIM, Hwa-Ok
- 申请人： MOLECUMETICS, LTD.
- 申请人地址： 2023-120th Avenue N.E., Suite 400 Bellevue, Washington 98005 US
- 专利权人： MOLECUMETICS, LTD.
- 当前专利权人： MOLECUMETICS, LTD.
- 当前专利权人地址： 2023-120th Avenue N.E., Suite 400 Bellevue, Washington 98005 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US846432 19970430
- 国际公布： WO9849168 19981105
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D498/04 ; A61K31/495 ; C07K5/06 ; G01N33/50 ; G01N33/53
摘要：
Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetics of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D487/00 | 在稠环系中含有氮原子作为仅有的杂环原子的杂环化合物，不包含在C07D451/00至C07D477/00组中 |
| --------C07D487/02 | .在稠合系中含有两个杂环 |
| ----------C07D487/04 | ..邻位稠合系 |