基本信息:
- 专利标题： METHOD FOR IMMORTALIZING CELLS
- 专利标题（中）：方法MAKE IMMORTAL细胞
- 申请号：EP97937274.5 申请日：1997-08-13
- 公开(公告)号：EP0956355B1 公开(公告)日：2004-10-20
- 发明人： FOSTER, Douglas, N. , FARRIS, James, A. , FOSTER, Linda, K.
- 申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA
- 申请人地址： 450 McNamara Alumni Center, 200 Oak Street SE Minneapolis, Minnesota 55455 US
- 专利权人： REGENTS OF THE UNIVERSITY OF MINNESOTA
- 当前专利权人： REGENTS OF THE UNIVERSITY OF MINNESOTA
- 当前专利权人地址： 450 McNamara Alumni Center, 200 Oak Street SE Minneapolis, Minnesota 55455 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US696376 19960813
- 国际公布： WO1998006827 19980219
- 主分类号： C12N15/79
- IPC分类号： C12N15/79 ; C12N5/10 ; C07K14/47 ; C12N7/00
摘要：
This invention relates to the introduction of p53 under the control of the metallothionein promoter into primary cells to produce immortalized cell lines. The cells are useful as substrates for viral propagation, as contaminant-free sources for recombinant protein production, for recombinant virus production and as cell substrates to support primary cells and improve virus yield during virus propagation.