发明公开
EP0947500A1 SULFONAMIDE AND CARBOXAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
失效
基本信息:
- 专利标题： SULFONAMIDE AND CARBOXAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
- 专利标题（中）：SULFONAMID-DERIVATE UND DIESE ALS AKTIVE BESTANDTEILE ENTHALTENDE MEDIKAMENTE
- 申请号：EP97947925.0 申请日：1997-12-12
- 公开(公告)号：EP0947500A1 公开(公告)日：1999-10-06
- 发明人： OHUCHIDA, Shuichi, Minase Res Ins ONO Pharm Co ltd , NAGAO, Yuuki, Minase Res. Inst. ONO Pharm. Co. Ltd
- 申请人： ONO PHARMACEUTICAL CO., LTD.
- 申请人地址： 1-5, Doshomachi 2-chome Chuo-ku Osaka 541 JP
- 专利权人： ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人： ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 1-5, Doshomachi 2-chome Chuo-ku Osaka 541 JP
- 代理机构： Bentham, Stephen
- 优先权： JP35381896 19961218; JP30505597 19971021
- 国际公布： WO9827053 19980625
- 主分类号： C07C233/25
- IPC分类号： C07C233/25 ; C07C233/75 ; C07C237/42 ; C07C311/13 ; C07C311/21 ; C07C311/17 ; C07C311/29 ; C07D213/76 ; C07D213/80 ; C07D307/42 ; C07D307/64 ; C07D307/68 ; C07D333/34 ; C07D333/40 ; A61K31/195 ; A61K31/24 ; A61K31/245 ; A61K31/34 ; A61K31/38
摘要：
The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient:
(wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z 1 is -COR 1 , -CH=CH-COR 1 etc.; Z 2 is H, alkyl etc.; Z 3 is single bond, alkylene; Z 4 is SO 2 , CO; Z 5 is alkyl, phenyl, heterocyclic ring etc.; R 2 is CONR 8 , O, S, NZ 6 , Z 7 -alkylene, alkylene etc.; R 3 is H, alkyl, halogen, CF 3 etc.; R 4 is H, (substituted) alkyl etc.; n, t is 1-4).
The compounds of the formula (I) can bind to receptors of PGE 2 and show antagonistic activity against the action thereof or agonistic activity. Therefore, they are considered to be useful as medicine for inhibition of uterine contraction, analgesics, antidiarrheals, sleep inducers, medicine for increase of vesical capacity or medicine for uterine contraction, cathartic, suppression of gastric acid secretion, antihypertensive or diuretic agents.
摘要（中）：
(wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z 1 is -COR 1 , -CH=CH-COR 1 etc.; Z 2 is H, alkyl etc.; Z 3 is single bond, alkylene; Z 4 is SO 2 , CO; Z 5 is alkyl, phenyl, heterocyclic ring etc.; R 2 is CONR 8 , O, S, NZ 6 , Z 7 -alkylene, alkylene etc.; R 3 is H, alkyl, halogen, CF 3 etc.; R 4 is H, (substituted) alkyl etc.; n, t is 1-4).
The compounds of the formula (I) can bind to receptors of PGE 2 and show antagonistic activity against the action thereof or agonistic activity. Therefore, they are considered to be useful as medicine for inhibition of uterine contraction, analgesics, antidiarrheals, sleep inducers, medicine for increase of vesical capacity or medicine for uterine contraction, cathartic, suppression of gastric acid secretion, antihypertensive or diuretic agents.
式（I）的磺酰胺或氨基酰胺衍生物和包含它们作为活性成分的药物组合物：其中A环，B环为碳环，杂环; Z 1为-COR 1 ，-CH = CH-COR 1等; Z 2是H，烷基等; Z 3是单键，亚烷基; Z 4是SO 2，CO; Z 5是烷基， 苯基，杂环等; R 2是CONR 8，O，S，NZ 6，Z 7 - 亚烷基，亚烷基等; R 3是H，烷基，卤素，CF 3等 R 4是H，（取代的）烷基等; n，t是1-4）。 式（I）的化合物可以与PGE2的受体结合，并且显示出对其作用或激动活性的拮抗活性。 因此，它们被认为可用作抑制子宫收缩，止痛剂，止泻药，睡眠诱导剂，用于增加膀胱容量的药物或药物用于子宫收缩，通气，抑制胃酸分泌，抗高血压或利尿剂的药物。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C233/00 | 羧酸酰胺 |
| --------C07C233/01 | .羧酰胺基的碳原子连接在氢原子或非环碳原子上 |
| ----------C07C233/02 | ..羧酰胺基的氮原子连接在氢原子或未取代烃基碳原子上 |
| ------------C07C233/24 | ...有由六元芳环碳原子连接在羧酰胺基的氮原子上的取代烃基 |
| --------------C07C233/25 | ....羧酰胺基的碳原子连接在氢原子或非饱和碳架的碳原子上 |