基本信息:
- 专利标题： Processes for producing optically active 2-amino-1-phenylethanol derivatives
- 专利标题（中）：生产光学活性2-氨基-1-苯乙醇衍生物的方法
- 申请号：EP99102724.4 申请日：1994-11-18
- 公开(公告)号：EP0924194A3 公开(公告)日：1999-06-30
- 发明人： Furukawa, Kazuaki
- 申请人： DAICEL CHEMICAL INDUSTRIES, LTD.
- 申请人地址： 1, Teppo-cho Sakai-shi, Osaka 590 JP
- 专利权人： DAICEL CHEMICAL INDUSTRIES, LTD.
- 当前专利权人： DAICEL CHEMICAL INDUSTRIES, LTD.
- 当前专利权人地址： 1, Teppo-cho Sakai-shi, Osaka 590 JP
- 代理机构： HOFFMANN - EITLE
- 优先权： JP28941993 19931118; JP31904693 19931124; JP4017294 19940310; JP8301494 19940421; JP18321794 19940804
- 主分类号： C07C213/04
- IPC分类号： C07C213/04 ; C07C213/08 ; C07C213/10
摘要：
A process is provided for producing a 2-amino-1phenylethanol derivative comprising;
allowing (a) a compound shown by the general Formula (III)
or (b) a compound shown by the general Formula (IV)
wherein R 1 , R 2 , R 3 , R 4 and R 5 represent a hydrogen atom etc; Z represents a hydrogen atom or a protective group for hydroxyl group and X represents a halogen atom, to react with a compound of the Formula Y-NH 2 wherein Y represents a hydrogen atom or a group which can be left in the reaction, further, when Y is the group which can be left in the reaction, allowing Y to be left, to obtain a compound shown by the general Formula (VI)
which comprises adding an acid to the reaction products containing the compound of the general Formula (VI) to precipitate or crystallize said compound as a salt and, thereby, isolating the compound of the general Formula (VI).
摘要（中）：
allowing (a) a compound shown by the general Formula (III)
or (b) a compound shown by the general Formula (IV)
wherein R 1 , R 2 , R 3 , R 4 and R 5 represent a hydrogen atom etc; Z represents a hydrogen atom or a protective group for hydroxyl group and X represents a halogen atom, to react with a compound of the Formula Y-NH 2 wherein Y represents a hydrogen atom or a group which can be left in the reaction, further, when Y is the group which can be left in the reaction, allowing Y to be left, to obtain a compound shown by the general Formula (VI)
which comprises adding an acid to the reaction products containing the compound of the general Formula (VI) to precipitate or crystallize said compound as a salt and, thereby, isolating the compound of the general Formula (VI).
提供了一种生产2-氨基-1-苯基乙醇衍生物的方法，该方法包括： （a）由通式（III）或（b）表示的化合物，其中R1，R2，R3，R4和R5表示氢原子等的通式（IV）表示的化合物; Z表示氢原子或羟基保护基，X表示卤原子，与式Y-NH2（其中Y表示氢原子或可留在反应中的基团）的化合物反应，此外，当 Y是可以留在反应中的基团，允许Y留下，得到通式（VI）所示的化合物，该方法包括向含有通式（VI）至 将所述化合物沉淀或结晶为盐，从而分离通式（VI）的化合物。
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C213/00 | 制备含与同一个碳架连接的氨基和羟基，氨基和醚化的羟基或氨基和酯化的羟基的化合物 |
| --------C07C213/04 | .氨或胺与烯烃氧化物或卤代醇的反应 |