发明公开
EP0923396A1 MEDICAMENT CARRIER WITH AGGLOMERATED LARGE MEDICAMENT PARTICLES AND RELATED METHOD OF MANUFACTURE THEREOF
失效
基本信息:
- 专利标题： MEDICAMENT CARRIER WITH AGGLOMERATED LARGE MEDICAMENT PARTICLES AND RELATED METHOD OF MANUFACTURE THEREOF
- 专利标题（中）：与团聚，BIG药物颗粒及其制造方法药物载体
- 申请号：EP97937527.0 申请日：1997-07-30
- 公开(公告)号：EP0923396A1 公开(公告)日：1999-06-23
- 发明人： VAN OORT, Michiel, Glaxo Wellcome Inc. , SACCHETTI, Mark Joseph, Glaxo Wellcome Inc.
- 申请人： GLAXO GROUP LIMITED
- 申请人地址： Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN GB
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN GB
- 代理机构： Thornley, Rachel Mary, et al
- 优先权： GB19960016047 19960731
- 国际公布： WO1998004308 19980205
- 主分类号： A61M15
- IPC分类号： A61M15
摘要：
A medicament carrier (10) having a first and a second spaced apart screen (12, 14) each of which has surfaces (12B, 14B) defining a plurality of interstices (12A, 14A). The carrier (10) contains powdered agglomerated medicament particles (SM) loaded onto the first screen surface (12B) such that the interstices (12A) of the first screen (12) are at least partially open and free of the agglomerated medicament particles (SM). When an air stream is provided to the carrier to entrain the agglomerated powdered medicament particles (SM) and move them from the first screen (12) through the interstices (14A) of the second screen (14), the agglomerated powdered medicament particles (SM) are sheared by air flow gradients created by the first and second screens (12, 14) and by contact with the surface (14B) of the second screen (14) to create particles of respirable particle size range. The carrier (10) can be used in a dry powder inhalator device.