基本信息:
- 专利标题： NEUROACTIVE STEROIDS OF THE ANDROSTANE AND PREGNANE SERIES
- 专利标题（中）：NEURO ACTIVE类固醇雄和孕
- 申请号：EP96919372.1 申请日：1996-06-06
- 公开(公告)号：EP0837874B1 公开(公告)日：2004-12-15
- 发明人： UPASANI, Ravindra, B. , FICK, David, B. , HOGENKAMP, Derk, J. , LAN, Nancy, C.
- 申请人： Euro-Celtique S.A.
- 申请人地址： 122 Boulevard de la Pétrusse 2330 Luxembourg LU
- 专利权人： Euro-Celtique S.A.
- 当前专利权人： Euro-Celtique S.A.
- 当前专利权人地址： 122 Boulevard de la Pétrusse 2330 Luxembourg LU
- 代理机构： Chapman, Paul William
- 优先权： US467404 19950606
- 国际公布： WO1996040043 19961219
- 主分类号： C07J1/00
- IPC分类号： C07J1/00 ; C07J43/00 ; C07J41/00
摘要：
The invention relates to 3 alpha -hydroxy, 17-(un)substituted derivatives of the androstane series and 3 alpha -hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having general structural formula (I), wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are further defined herein and the dotted lines are single or double bonds. The structure includes androstanes pregnanes (R4 = methyl), 19-norandrostanes, and norpregnanes (R4 = H).