基本信息:
- 专利标题： 2-SUBSTITUTED ADENOSINES WITH A-2 RECEPTOR AFFINITY
- 专利标题（中）：2-取代腺苷WITH A-2受体的亲和力。
- 申请号：EP93921304.0 申请日：1993-09-02
- 公开(公告)号：EP0662975A1 公开(公告)日：1995-07-19
- 发明人： PEET, Norton, P. , BORCHERDING, David, R. , LENTZ, Nelsen, L. , WEINTRAUB, Philip, M.
- 申请人： MERRELL DOW PHARMACEUTICALS INC.
- 申请人地址： P.O. Box 156300 2110 East Galbraith Road Cincinnati Ohio 45215-6300 US
- 专利权人： MERRELL DOW PHARMACEUTICALS INC.
- 当前专利权人： MERRELL PHARMACEUTICALS INC.
- 当前专利权人地址： MERRELL PHARMACEUTICALS INC.
- 代理机构： VOSSIUS & PARTNER
- 优先权： US19920954180 19920930
- 国际公布： WO1994007905 19940414
- 主分类号： C07H1
- IPC分类号： C07H1 ; A61K31 ; A61P9 ; C07H19
摘要：
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine agonists are disclosed. From (in vitro) studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity (in vitro) correlates with adenosine receptor activity (in vivo). Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.