EP0593437B1 GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
失效 - 权利终止
基本信息:
- 专利标题： GEM-DIPHOSPHONIC ACIDS, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
- 专利标题（中）：创业板二膦酸，其制造方法相同，含药物
- 申请号：EP90915106.0 申请日：1990-10-11
- 公开(公告)号：EP0593437B1 公开(公告)日：1996-05-08
- 发明人： TOGNELLA, Sergio , LIVI, Valeria , MENTA, Ernesto , SPINELLI, Silvano
- 申请人： BOEHRINGER MANNHEIM ITALIA S.P.A.
- 申请人地址： Via S. Uguzzone, 5 I-20126 Milano IT
- 专利权人： BOEHRINGER MANNHEIM ITALIA S.P.A.
- 当前专利权人： BOEHRINGER MANNHEIM ITALIA S.P.A.
- 当前专利权人地址： Via S. Uguzzone, 5 I-20126 Milano IT
- 代理机构： Weber, Manfred, Dr.
- 优先权： IT2200489 19891012
- 国际公布： WO9105791 19910502
- 主分类号： C07F9/38
- IPC分类号： C07F9/38 ; C07F9/564 ; A61K31/66
摘要：
Diphosphonic acids of formula (I), wherein R1 and R2 are hydrogen or C1-C4 alkyl; (A) is hydrogen, halogen, hydroxy or C1-C12 alkyl; (B) is a bond, a C1-C8 alkylene chain, a cycloalkylalkylene chain, an alkylene chain substituted by cyclohexyl or cyclopentyl groups, or an aralkyl chain, an alkyl chain containing an heteroatom (O, S or N-CH3) or an ureido residue -(CH2)n1-NHCONH -(CH2)n- with n ranging from 1 to 5, R3 is hydrogen, C1-C9 alkyl, C3-C6 cycloalkyl, benzyl, phenyl or p-methoxybenzyl; (C) is C1-C5 alkyl, phenyl or an aralkyl chain; R4 is hydrogen, C1-C4 alkyl or an amino group optionally substituted by alkyl, phenyl, benzyl, p-methoxybenzyl, acyl, amminoacidic or peptide groups; R5 and R6 are 2-haloethyl or together form a 1-aziridinyl residue, are useful as antitumor agent.
公开/授权文献:
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07F | 含除碳、氢、卤素、氧、氮、硫、硒或碲以外的其他元素的无环，碳环或杂环化合物 |
| ------C07F9/00 | 含周期表第Ⅴ族元素的化合物 |
| --------C07F9/02 | .磷化合物 |
| ----------C07F9/06 | ..无P—C键的 |
| ------------C07F9/38 | ...膦酸；硫代膦酸 |