EP0527199B1 Compositions for use in a method for treating a human suffering from multiple sclerosis
有权
基本信息:
- 专利标题： Compositions for use in a method for treating a human suffering from multiple sclerosis
- 专利标题（中）：组合物的方法中使用的多发性硬化症治疗的人的患者
- 申请号：EP91909565.3 申请日：1991-05-01
- 公开(公告)号：EP0527199B1 公开(公告)日：1996-07-24
- 发明人： STEINMAN, Lawrence , OKSENBERG, Jorge , BERNARD, Claude
- 申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 申请人地址： Stanford University Stanford California 94305 US
- 专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人地址： Stanford University Stanford California 94305 US
- 代理机构： Kraus, Walter, Dr.
- 优先权： US517245 19900501
- 国际公布： WO9117268 19911114
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/53 ; G01N33/567 ; G01N33/547 ; C12N5/08
摘要：
Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T-cells associated with combatting neoproliferative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and therapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue enhancing the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.