基本信息:
- 专利标题： Retroviral protease inhibiting compounds
- 专利标题（中）：逆转录病毒蛋白酶
- 申请号：EP90109319.5 申请日：1990-05-17
- 公开(公告)号：EP0402646A1 公开(公告)日：1990-12-19
- 发明人： Kempf, Dale J. , Norbeck, Daniel W. , Erickson, John W. , Codacovi, Lynn M. , Sham, Hing Leung , Plattner, Jacob J.
- 申请人： ABBOTT LABORATORIES
- 申请人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： One Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing.
- 优先权： US355945 19890523; US405604 19890908; US456124 19891222; US518730 19900509
- 主分类号： C07D213/40
- IPC分类号： C07D213/40 ; C07D213/56 ; C07D211/44 ; C07D215/14 ; C07D211/34 ; C07D215/18 ; C07D295/26 ; C07D295/145 ; C07D303/04 ; C07D303/23 ; C07D303/36
摘要：
A retroviral protease inhibiting compound of the formula
or a pharmaceutical acceptable salt, prodrug or ester thereof, wherein X is a linking group;
A is
(1) substituted amino,
(2) substituted carbonyl,
(3) functionalized imino,
(4) functionalized alkyl,
(5) functionalized acyl,
(6) functionalized heterocyclic or
(7) functionalized (heterocyclic)alkyl; and B is
(1) substituted carbonyl independently defined as herein,
(2) substituted amino independently defined as herein,
(3) functionalized imino independently defined as herein,
(4) functionalized alkyl independently defined as herein,
(5) functionalized acyl independently defined as herein,
(6) functionalized heterocyclic independently defined as herein or
(7) functionalized (heterocyclic)alkyl independently defined as herein.
摘要（中）：
or a pharmaceutical acceptable salt, prodrug or ester thereof, wherein X is a linking group;
A is
(1) substituted amino,
(2) substituted carbonyl,
(3) functionalized imino,
(4) functionalized alkyl,
(5) functionalized acyl,
(6) functionalized heterocyclic or
(7) functionalized (heterocyclic)alkyl; and B is
(1) substituted carbonyl independently defined as herein,
(2) substituted amino independently defined as herein,
(3) functionalized imino independently defined as herein,
(4) functionalized alkyl independently defined as herein,
(5) functionalized acyl independently defined as herein,
(6) functionalized heterocyclic independently defined as herein or
(7) functionalized (heterocyclic)alkyl independently defined as herein.
式A-X-B的逆转录病毒蛋白酶抑制化合物或其药学上可接受的盐，前药或酯，其中X是连接基团; A是（1）取代氨基，（2）取代羰基，（3）官能化亚氨基，（4）官能化烷基，（5）官能化酰基，（6）官能化杂环或（7）官能化（杂环）烷基; 并且B是本文独立定义的（1）取代的羰基，（2）独立地定义如本文的取代氨基，（3）如本文独立定义的官能化亚氨基，（4）独立地定义如本文的官能化烷基，（5）独立定义的官能化酰基 如本文所述，（6）如本文独立定义的官能化杂环或（7）如本文独立定义的官能化（杂环）烷基。 Ø
公开/授权文献:
- EP0402646B1 Retroviral protease inhibiting compounds 公开/授权日：1998-07-22
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D213/00 | 杂环化合物，含六元环、不与其他环稠合、有1个氮原子作为仅有的杂环原子、环原子间或环原子与非环原子间有3个或更多个双键 |
| --------C07D213/02 | .环原子间或环原子与非环原子间有3个双键 |
| ----------C07D213/04 | ..在环氮原子与非环原子间没有键或只有氢或碳原子直接连在环氮原子上 |
| ------------C07D213/06 | ...除了环氮原子外，只含氢和碳原子 |
| --------------C07D213/28 | ....被以单键键合的氧原子或硫原子取代的基 |
| ----------------C07D213/40 | .....被酰化的取代基的氮原子 |