基本信息:
- 专利标题： Antitussive and mucus regulating 2-substituted thiazolidines
- 专利标题（中）：抗生素和调节2代替噻唑烷酮
- 申请号：EP85109445 申请日：1985-07-26
- 公开(公告)号：EP0169581A3 公开(公告)日：1987-05-13
- 发明人： Gandolfi, Carmelo A. , Spinelli, Silvano , Tofanetti, Odoardo , Russo, Raimondo , Tognella, Sergio
- 申请人： BOEHRINGER BIOCHEMIA ROBIN S.p.A.
- 专利权人： BOEHRINGER BIOCHEMIA ROBIN S.p.A.
- 当前专利权人： BOEHRINGER MANNHEIM ITALIA S.P.A. TE MILAAN, ITALI
- 当前专利权人地址： BOEHRINGER MANNHEIM ITALIA S.P.A. TE MILAAN, ITALI
- 优先权： GB8419254 19840727; GB8517553 19850711
- 主分类号： C07D277/04
- IPC分类号： C07D277/04 ; A61K31/425
摘要：
2-Substituted thiazolidines compounds having formula I
wherein X is a CH 2 , O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R, is hydrogen or a group of formula
R 2 is hydrogen or a free or esterified carboxy group, R a and R b are hydrogen or methyl, p is zero or 1, R 3 is hydrogen, a C 1 -C 2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.
wherein X is a CH 2 , O or S, R is hydroxy or an acyloxy, alkyloxy, alkenyloxy or alkinyloxy group, R, is hydrogen or a group of formula
R 2 is hydrogen or a free or esterified carboxy group, R a and R b are hydrogen or methyl, p is zero or 1, R 3 is hydrogen, a C 1 -C 2 alkylsulphonyl group, a phenyl or p-Cl phenyl, p-methylsulphonyl group or an acyl group; are useful as mucus regulating, antitussive and antibronchospastic agents.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D277/00 | 杂环化合物，含有1,3-噻唑或氢化1,3-噻唑环 |
| --------C07D277/02 | .不和其他环稠合 |
| ----------C07D277/04 | ..环原子间或环原子与非环原子间没有双键 |