基本信息:
- 专利标题： Composition for technetium-99m labelling of proteinaceous material
- 专利标题（中）：蛋白质99M标记物的组成
- 申请号：EP85900781.7 申请日：1985-01-18
- 公开(公告)号：EP0169232B1 公开(公告)日：1990-04-25
- 发明人： INSTITUTT FOR ENERGITEKNIKK , SUNDREHAGEN, Erling
- 申请人： INSTITUTT FOR ENERGITEKNIKK , SUNDREHAGEN, Erling
- 申请人地址： P.O. Box 40 N-2007 Kjeller NO
- 专利权人： INSTITUTT FOR ENERGITEKNIKK,SUNDREHAGEN, Erling
- 当前专利权人： INSTITUTT FOR ENERGITEKNIKK,SUNDREHAGEN, Erling
- 当前专利权人地址： P.O. Box 40 N-2007 Kjeller NO
- 代理机构： Lambert, Hugh Richmond
- 优先权： SE8400325 19840123
- 国际公布： WO8503231 19850801
- 主分类号： A61K49/02
- IPC分类号： A61K49/02
摘要：
Chemical compositions for radioactive technetium-99m labelling of proteinaceous material include benzoic acid derivative or a water soluble salt thereof, selected from the group of aminobenzoic, monohydroxy- and dihydroxy-benzoic acid or salt thereof and a stannous salt. The composition may be in the form of a ready-to-use composition of benzoic acid derivative and stannous salt with proteins to be labelled. Ready-to-use compositions with proteins can be prepared in dry form for instant preparation by combination with a radioactive pertechnetate solution. The labelling process is advantageously performed by reduction of pertechnetate by means of divalent tin in a benzoic acid derivative containing solution of the stannous salt. The pH and ionic strength of the solution depends on the proteins or cells which are to be labelled. The compositions are suitable for detection or scintigraphic depiction of processes in human beings or other biological organisms.